Identification of non-covalent 3C-like protease inhibitors against severe acute respiratory syndrome coronavirus-2 via virtual screening of a Korean compound library

The outbreak of coronavirus (CoV) disease 2019 (COVID-19) caused by the severe acute respiratory syndrome CoV-2 (SARS-CoV-2) has turned into a pandemic. The enzyme 3C-like protease (3CL(pro)) is essential for the maturation of viral polyproteins in SARS-CoV-2 and is therefore regarded as a key drug...

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Bibliographic Details
Published in:Bioorg Med Chem Lett
Main Authors: Lee, Joo-Youn, Kuo, Chih-Jung, Shin, Jin Soo, Jung, Eunhye, Liang, Po-Huang, Jung, Young-Sik
Format: Artigo
Language:Inglês
Published: The Authors. Published by Elsevier Ltd. 2021
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC8091729/
https://ncbi.nlm.nih.gov/pubmed/33957246
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2021.128067
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