Inositol 1,4,5-trisphosphate 3-kinase B promotes Ca(2+) mobilization and the inflammatory activity of dendritic cells

Innate immune responses to Gram-negative bacteria depend on the recognition of lipopolysaccharide (LPS) by a receptor complex that includes CD14 and TLR4. In dendritic cells (DCs), CD14 enhances the activation not only of TLR4 but also that of the NFAT family of transcription factors, which suppress...

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Gepubliceerd in:Sci Signal
Hoofdauteurs: Marongiu, Laura, Mingozzi, Francesca, Cigni, Clara, Marzi, Roberta, Di Gioia, Marco, Garrè, Massimiliano, Parazzoli, Dario, Sironi, Laura, Collini, Maddalena, Sakaguchi, Reiko, Morii, Takashi, Crosti, Mariacristina, Moro, Monica, Schurmans, Stéphane, Catelani, Tiziano, Rotem, Rany, Colombo, Miriam, Shears, Stephen, Prosperi, Davide, Zanoni, Ivan, Granucci, Francesca
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2021
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Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8091591/
https://ncbi.nlm.nih.gov/pubmed/33785611
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scisignal.aaz2120
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