Caspase inhibition prolongs inflammation by promoting a signaling complex with activated RIPK1

Activation of inflammation by lipopolysaccharide (LPS) is an important innate immune response. Here we investigated the contribution of caspases to the LPS-mediated inflammatory response and discovered distinctive temporal roles of RIPK1 in mediating proinflammatory cytokine production when caspases...

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Veröffentlicht in:J Cell Biol
Hauptverfasser: Huang, Xinyue, Tan, Shuixia, Li, Yanxia, Cao, Shuangyi, Li, Xingyan, Pan, Heling, Shan, Bing, Qian, Lihui, Yuan, Junying
Format: Artigo
Sprache:Inglês
Veröffentlicht: Rockefeller University Press 2021
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8091129/
https://ncbi.nlm.nih.gov/pubmed/33914027
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.202007127
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