Distinct intramolecular interactions regulate autoinhibition of vinculin binding in αT-catenin and αE-catenin

α-Catenin binds directly to β-catenin and connects the cadherin–catenin complex to the actin cytoskeleton. Tension regulates α-catenin conformation. Actomyosin-generated force stretches the middle (M)-region to relieve autoinhibition and reveal a binding site for the actin-binding protein vinculin....

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Pubblicato in:J Biol Chem
Autori principali: Heier, Jonathon A., Pokutta, Sabine, Dale, Ian W., Kim, Sun Kyung, Hinck, Andrew P., Weis, William I., Kwiatkowski, Adam V.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Biochemistry and Molecular Biology 2021
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC8091058/
https://ncbi.nlm.nih.gov/pubmed/33771561
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jbc.2021.100582
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