Distinct intramolecular interactions regulate autoinhibition of vinculin binding in αT-catenin and αE-catenin

α-Catenin binds directly to β-catenin and connects the cadherin–catenin complex to the actin cytoskeleton. Tension regulates α-catenin conformation. Actomyosin-generated force stretches the middle (M)-region to relieve autoinhibition and reveal a binding site for the actin-binding protein vinculin....

Popoln opis

Shranjeno v:
Bibliografske podrobnosti
izdano v:J Biol Chem
Main Authors: Heier, Jonathon A., Pokutta, Sabine, Dale, Ian W., Kim, Sun Kyung, Hinck, Andrew P., Weis, William I., Kwiatkowski, Adam V.
Format: Artigo
Jezik:Inglês
Izdano: American Society for Biochemistry and Molecular Biology 2021
Teme:
Research Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC8091058/
https://ncbi.nlm.nih.gov/pubmed/33771561
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jbc.2021.100582
Oznake: Označite
Brez oznak, prvi označite!

Podobne knjige/članki