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Distinct intramolecular interactions regulate autoinhibition of vinculin binding in αT-catenin and αE-catenin
α-Catenin binds directly to β-catenin and connects the cadherin–catenin complex to the actin cytoskeleton. Tension regulates α-catenin conformation. Actomyosin-generated force stretches the middle (M)-region to relieve autoinhibition and reveal a binding site for the actin-binding protein vinculin....
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| Опубликовано в: : | J Biol Chem |
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| Главные авторы: | , , , , , , |
| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
American Society for Biochemistry and Molecular Biology
2021
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC8091058/ https://ncbi.nlm.nih.gov/pubmed/33771561 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jbc.2021.100582 |
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