PECAM‐1 supports leukocyte diapedesis by tension‐dependent dephosphorylation of VE‐cadherin

Leukocyte extravasation is an essential step during the immune response and requires the destabilization of endothelial junctions. We have shown previously that this process depends in vivo on the dephosphorylation of VE‐cadherin‐Y731. Here, we reveal the underlying mechanism. Leukocyte‐induced stim...

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Bibliographic Details
Published in:EMBO J
Main Authors: Arif, Nida, Zinnhardt, Maren, Nyamay’Antu, Alengo, Teber, Denise, Brückner, Randy, Schaefer, Kerstin, Li, Yu‐Tung, Trappmann, Britta, Grashoff, Carsten, Vestweber, Dietmar
Format: Artigo
Language:Inglês
Published: John Wiley and Sons Inc. 2021
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC8090850/
https://ncbi.nlm.nih.gov/pubmed/33604918
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/embj.2020106113
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