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PECAM‐1 supports leukocyte diapedesis by tension‐dependent dephosphorylation of VE‐cadherin

Leukocyte extravasation is an essential step during the immune response and requires the destabilization of endothelial junctions. We have shown previously that this process depends in vivo on the dephosphorylation of VE‐cadherin‐Y731. Here, we reveal the underlying mechanism. Leukocyte‐induced stim...

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Detalhes bibliográficos
Publicado no:EMBO J
Main Authors: Arif, Nida, Zinnhardt, Maren, Nyamay’Antu, Alengo, Teber, Denise, Brückner, Randy, Schaefer, Kerstin, Li, Yu‐Tung, Trappmann, Britta, Grashoff, Carsten, Vestweber, Dietmar
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2021
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8090850/
https://ncbi.nlm.nih.gov/pubmed/33604918
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/embj.2020106113
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