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Selective Somatostatin 5 (SST5) and Somatostatin 2 (SST2) Nonpeptide Agonists Potently Suppress Glucose- and Tolbutamide-Stimulated Dynamic Insulin Secretion From Isolated Human Islets

Congenital hyperinsulinism (HI) is the most common cause of persistent hypoglycemia in newborns and infants and arises from dysregulated insulin secretion. Rapid recognition and treatment are vital to prevent seizures, permanent developmental delays, coma, or even death. Very few medical options exi...

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Detalhes bibliográficos
Publicado no:J Endocr Soc
Main Authors: Rico, Elizabeth, Zhao, Jian, Chen, Mi, Kusnetzow, Ana Karin, Zhu, Yun Fei, Betz, Stephen F
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2021
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8089509/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1210/jendso/bvab048.663
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