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Selective Somatostatin 5 (SST5) and Somatostatin 2 (SST2) Nonpeptide Agonists Potently Suppress Glucose- and Tolbutamide-Stimulated Dynamic Insulin Secretion From Isolated Human Islets

Congenital hyperinsulinism (HI) is the most common cause of persistent hypoglycemia in newborns and infants and arises from dysregulated insulin secretion. Rapid recognition and treatment are vital to prevent seizures, permanent developmental delays, coma, or even death. Very few medical options exi...

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Bibliografiske detaljer
Udgivet i:J Endocr Soc
Main Authors: Rico, Elizabeth, Zhao, Jian, Chen, Mi, Kusnetzow, Ana Karin, Zhu, Yun Fei, Betz, Stephen F
Format: Artigo
Sprog:Inglês
Udgivet: Oxford University Press 2021
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8089509/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1210/jendso/bvab048.663
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