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Distinct Calcium Signaling for Wildtype, Loss-of-Function and Gain-of-Function Human MC4R Variants

There is compelling evidence for human melanocortin-4-receptor (hMC4R) playing a critical function regulating energy balance; yet signal transduction pathways contributing to this are unclear. The hMC4R activates multiple signaling pathways, including induced increases in cAMP and mobilization of in...

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Detalhes bibliográficos
Publicado no:J Endocr Soc
Main Authors: Kumar, Shree S, Mountjoy, Kathleen Grace
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2021
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8089185/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1210/jendso/bvab048.087
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