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SUN-LB107 Functional Characterisation of Human Heterozygous Non-Synonymous MC3R Variants

Background: Melanocortin 3 receptor (MC3R) is a member of the melanocortin family of G-protein coupled receptors predominantly expressed in hypothalamic tissue. Rodent models have implicated MC3R in the pathogenesis of obesity, however in humans the relationship between obesity phenotypes and impair...

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Detalhes bibliográficos
Publicado no:J Endocr Soc
Main Authors: Melvin, Audrey, Cowan, Ceili, Lam, Brian, Buller, Sophie, Rainbow, Kara, Yeo, Giles S, O’Rahilly, Stephen
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2020
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7209424/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1210/jendso/bvaa046.2097
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