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Binding pathway determines norepinephrine selectivity for the human β(1)AR over β(2)AR

Beta adrenergic receptors (βARs) mediate physiologic responses to the catecholamines epinephrine and norepinephrine released by the sympathetic nervous system. While the hormone epinephrine binds β(1)AR and β(2)AR with similar affinity, the smaller neurotransmitter norepinephrine is approximately te...

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Bibliografske podrobnosti
izdano v:Cell Res
Main Authors: Xu, Xinyu, Kaindl, Jonas, Clark, Mary J., Hübner, Harald, Hirata, Kunio, Sunahara, Roger K., Gmeiner, Peter, Kobilka, Brian K., Liu, Xiangyu
Format: Artigo
Jezik:Inglês
Izdano: Springer Singapore 2020
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC8089101/
https://ncbi.nlm.nih.gov/pubmed/33093660
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41422-020-00424-2
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