Dysregulation of the centrosome induced by BRCA1 deficiency contributes to tissue‐specific carcinogenesis

Alterations in breast cancer gene 1 (BRCA1), a tumor suppressor gene, increase the risk of breast and ovarian cancers. BRCA1 forms a heterodimer with BRCA1‐associated RING domain protein 1 (BARD1) and functions in multiple cellular processes, including DNA repair and centrosome regulation. BRCA1 act...

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Shranjeno v:
Bibliografske podrobnosti
izdano v:Cancer Sci
Main Authors: Yoshino, Yuki, Fang, Zhenzhou, Qi, Huicheng, Kobayashi, Akihiro, Chiba, Natsuko
Format: Artigo
Jezik:Inglês
Izdano: John Wiley and Sons Inc. 2021
Teme:
Review Articles
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC8088922/
https://ncbi.nlm.nih.gov/pubmed/33606355
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/cas.14859
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