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Evaluation of site-specific homologous recombination activity of BRCA1 by direct quantitation of gene editing efficiency
Homologous recombination (HR) contributes to the repair of DNA double-strand breaks (DSBs) and inter-strand crosslinks. The HR activity in cancer cells can be used to predict their sensitivity to DNA-damaging agents that cause these damages. To evaluate HR activity, we developed a system called Assa...
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| Pubblicato in: | Sci Rep |
|---|---|
| Autori principali: | , , , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
Nature Publishing Group UK
2019
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6367331/ https://ncbi.nlm.nih.gov/pubmed/30733539 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-018-38311-x |
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