Ketamine Induces Lasting Antidepressant Effects by Modulating the NMDAR/CaMKII-Mediated Synaptic Plasticity of the Hippocampal Dentate Gyrus in Depressive Stroke Model

BACKGROUND: Ketamine has been shown to possess lasting antidepressant properties. However, studies of the mechanisms involved in its effects on poststroke depression are nonexistent. METHODS: To investigate these mechanisms, Sprague-Dawley rats were treated with a single local dose of ketamine after...

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Detalhes bibliográficos
Publicado no:Neural Plast
Main Authors: Abdoulaye, Idriss Ali, Wu, Shan-shan, Chibaatar, Enkhmurun, Yu, Da-fan, Le, Kai, Cao, Xue-jin, Guo, Yi-jing
Formato: Artigo
Idioma:Inglês
Publicado em: Hindawi 2021
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8088363/
https://ncbi.nlm.nih.gov/pubmed/33981335
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2021/6635084
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