Combined VEGFR and MAPK pathway inhibition in angiosarcoma

Angiosarcoma is an aggressive malignancy of endothelial cells that carries a high mortality rate. Cytotoxic chemotherapy can elicit clinical responses, but the duration of response is limited. Sequencing reveals multiple mutations in angiogenesis pathways in angiosarcomas, particularly in vascular e...

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Vydáno v:Sci Rep
Hlavní autoři: Wagner, Michael J., Lyons, Yasmin A., Siedel, Jean H., Dood, Robert, Nagaraja, Archana S., Haemmerle, Monika, Mangala, Lingegowda S., Chanana, Pritha, Lazar, Alexander J., Wang, Wei-Lien, Ravi, Vinod, Holland, Eric C., Sood, Anil K.
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group UK 2021
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC8087824/
https://ncbi.nlm.nih.gov/pubmed/33931674
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-021-88703-9
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