PTGER3 induces ovary tumorigenesis and confers resistance to cisplatin therapy through up-regulation Ras-MAPK/Erk-ETS1-ELK1/CFTR1 axis

BACKGROUND: Inflammatory mediator prostaglandin E2–prostaglandin E2 receptor EP3 (PTGER3) signaling is critical for tumor-associated angiogenesis, tumor growth, and chemoresistance. However, the mechanism underlying these effects in ovarian cancer is not known. METHODS: An association between higher...

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Sparad:
Bibliografiska uppgifter
I publikationen:EBioMedicine
Huvudupphovsmän: Rodriguez-Aguayo, Cristian, Bayraktar, Emine, Ivan, Cristina, Aslan, Burcu, Mai, Junhua, He, Guangan, Mangala, Lingegowda S., Jiang, Dahai, Nagaraja, Archana S., Ozpolat, Bulent, Chavez-Reyes, Arturo, Ferrari, Mauro, Mitra, Rahul, Siddik, Zahid H., Shen, Haifa, Yang, Xianbin, Sood, Anil K., Lopez-Berestein, Gabriel
Materialtyp: Artigo
Språk:Inglês
Publicerad: Elsevier 2019
Ämnen:
Research paper
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC6411965/
https://ncbi.nlm.nih.gov/pubmed/30655206
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ebiom.2018.11.045
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