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Characterizing the Lassa Virus Envelope Glycoprotein Membrane Proximal External Region for Its Role in Fusogenicity

The membrane-proximal external region (MPER) of Lassa virus (LASV) glycoprotein complex (GPC) is critical in modulating its functionality. Till now, the high-resolution structure of the intact GPC, including MPER is not available. In this study, we used alanine substitution to scan all 16 residues l...

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Detalhes bibliográficos
Publicado no:Virol Sin
Main Authors: Cao, Junyuan, Zhang, Guangshun, Zhou, Minmin, Liu, Yang, Xiao, Gengfu, Wang, Wei
Formato: Artigo
Idioma:Inglês
Publicado em: Springer Singapore 2020
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8087742/
https://ncbi.nlm.nih.gov/pubmed/32897505
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s12250-020-00286-3
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