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Avoiding a sticky situation: bypassing the mucus barrier for improved local drug delivery

The efficacy of drugs administered by traditional routes is limited by numerous biological barriers that preclude reaching the intended site of action. Further, full body systemic exposure leads to dose-limiting, off-target side effects. Topical formulations may provide more efficacious drug and nuc...

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Bibliografiska uppgifter
I publikationen:Trends Mol Med
Huvudupphovsmän: Zierden, Hannah C., Josyula, Aditya, Shapiro, Rachel L., Hsueh, Henry, Hanes, Justin, Ensign, Laura M.
Materialtyp: Artigo
Språk:Inglês
Publicerad: 2021
Ämnen:
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC8087626/
https://ncbi.nlm.nih.gov/pubmed/33414070
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molmed.2020.12.001
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