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Avoiding a sticky situation: bypassing the mucus barrier for improved local drug delivery

The efficacy of drugs administered by traditional routes is limited by numerous biological barriers that preclude reaching the intended site of action. Further, full body systemic exposure leads to dose-limiting, off-target side effects. Topical formulations may provide more efficacious drug and nuc...

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Detalhes bibliográficos
Publicado no:Trends Mol Med
Main Authors: Zierden, Hannah C., Josyula, Aditya, Shapiro, Rachel L., Hsueh, Henry, Hanes, Justin, Ensign, Laura M.
Formato: Artigo
Idioma:Inglês
Publicado em: 2021
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8087626/
https://ncbi.nlm.nih.gov/pubmed/33414070
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molmed.2020.12.001
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