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Sulfated glycans engage the Ang/Tie pathway to regulate vascular development

The angiopoietin (Ang)/Tie pathway is essential for the proper maturation and remodeling of the vasculature. Despite its importance in disease, the mechanisms that control signal transduction through this pathway are poorly understood. Here, we demonstrate that heparan sulfate glycosaminoglycans (HS...

詳細記述

保存先:
書誌詳細
出版年:Nat Chem Biol
主要な著者: Griffin, Matthew E., Sorum, Alexander W., Miller, Gregory M., Goddard, William A., Hsieh-Wilson, Linda C.
フォーマット: Artigo
言語:Inglês
出版事項: 2020
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC8087285/
https://ncbi.nlm.nih.gov/pubmed/33020664
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41589-020-00657-7
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