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A Designed Angiopoietin-1 Variant, Dimeric CMP-Ang1 Activates Tie2 and Stimulates Angiogenesis and Vascular Stabilization in N-glycan Dependent Manner
Angiopoietin-1 (Ang1), a potential growth factor for therapeutic angiogenesis and vascular stabilization, is known to specifically cluster and activate Tie2 in high oligomeric forms, which is a unique and essential process in this ligand-receptor interaction. However, highly oligomeric native Ang1 a...
Shranjeno v:
izdano v: | Sci Rep |
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Main Authors: | , , , , , , , , |
Format: | Artigo |
Jezik: | Inglês |
Izdano: |
Nature Publishing Group
2015
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Teme: | |
Online dostop: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4609988/ https://ncbi.nlm.nih.gov/pubmed/26478188 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep15291 |
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