COMP-Ang1: A designed angiopoietin-1 variant with nonleaky angiogenic activity

Angiopoietin-1 (Ang1) has potential therapeutic applications in inducing angiogenesis, enhancing endothelial cell survival, and preventing vascular leakage. However, production of Ang1 is hindered by aggregation and insolubility resulting from disulfide-linked higher-order structures. Here, by repla...

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Bibliografiske detaljer
Udgivet i:Proc Natl Acad Sci U S A
Main Authors: Cho, Chung-Hyun, Kammerer, Richard A., Lee, Hyuek Jong, Steinmetz, Michel O., Ryu, Young Shin, Lee, Sung Ho, Yasunaga, Kunio, Kim, Kyung-Tae, Kim, Injune, Choi, Han-Ho, Kim, Won, Kim, Sung Hyun, Park, Sung Kwang, Lee, Gyun Min, Koh, Gou Young
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2004
Fag:
Biological Sciences
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC397420/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/15060279/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.0307574101
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