COMP-Ang1: A designed angiopoietin-1 variant with nonleaky angiogenic activity

Angiopoietin-1 (Ang1) has potential therapeutic applications in inducing angiogenesis, enhancing endothelial cell survival, and preventing vascular leakage. However, production of Ang1 is hindered by aggregation and insolubility resulting from disulfide-linked higher-order structures. Here, by repla...

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Hlavní autoři: Cho, Chung-Hyun, Kammerer, Richard A., Lee, Hyuek Jong, Steinmetz, Michel O., Ryu, Young Shin, Lee, Sung Ho, Yasunaga, Kunio, Kim, Kyung-Tae, Kim, Injune, Choi, Han-Ho, Kim, Won, Kim, Sung Hyun, Park, Sung Kwang, Lee, Gyun Min, Koh, Gou Young
Médium: Artigo
Jazyk:Inglês
Vydáno: National Academy of Sciences 2004
Témata:
Biological Sciences
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC397420/
https://ncbi.nlm.nih.gov/pubmed/15060279
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0307574101
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