17α-Estradiol Modulates IGF1 and Hepatic Gene Expression in a Sex-Specific Manner

Aging is the greatest risk factor for most chronic diseases. The somatotropic axis is one of the most conserved biological pathways that regulates aging across species. 17α-Estradiol (17α-E2), a diastereomer of 17β-estradiol (17β-E2), was recently found to elicit health benefits, including improved...

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Udgivet i:J Gerontol A Biol Sci Med Sci
Main Authors: Sidhom, Silvana, Schneider, Augusto, Fang, Yimin, McFadden, Samuel, Darcy, Justin, Sathiaseelan, Roshini, Palmer, Allyson K, Steyn, Frederik J, Grillari, Johannes, Kopchick, John J, Bartke, Andrzej, Siddiqi, Shadab, Masternak, Michal M, Stout, Michael B
Format: Artigo
Sprog:Inglês
Udgivet: Oxford University Press 2020
Fag:
THE JOURNAL OF GERONTOLOGY: Biological Sciences
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8087270/
https://ncbi.nlm.nih.gov/pubmed/32857104
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/gerona/glaa215
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