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17α-estradiol promotes ovarian aging in growth hormone receptor knockout mice, but not wild-type littermates
Growth hormone receptor knockout mice (GHRKO) have reduced body size and increased insulin sensitivity. These mice are known for having extended lifespan, healthspan and female reproductive longevity. Seventeen α-estradiol (17α-E2) is reported to increase insulin sensitivity and extend lifespan in m...
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| Опубликовано в: : | Exp Gerontol |
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| Главные авторы: | , , , , , , , |
| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
2019
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6911620/ https://ncbi.nlm.nih.gov/pubmed/31698046 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.exger.2019.110769 |
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