17α-estradiol promotes ovarian aging in growth hormone receptor knockout mice, but not wild-type littermates

Growth hormone receptor knockout mice (GHRKO) have reduced body size and increased insulin sensitivity. These mice are known for having extended lifespan, healthspan and female reproductive longevity. Seventeen α-estradiol (17α-E2) is reported to increase insulin sensitivity and extend lifespan in m...

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Publicat a:Exp Gerontol
Autors principals: Isola, José V. V., Zanini, Bianka M., Sidhom, Silvana, Kopchick, John J., Bartke, Andrzej, Masternak, Michal M., Stout, Michael B., Schneider, Augusto
Format: Artigo
Idioma:Inglês
Publicat: 2019
Matèries:
Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6911620/
https://ncbi.nlm.nih.gov/pubmed/31698046
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.exger.2019.110769
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