Pirh2, an E3 ligase, regulates the AIP4–p73 regulatory pathway by modulating AIP4 expression and ubiquitination

Pirh2 is an E3 ligase belonging to the RING-H2 family and shown to bind, ubiquitinate and downregulate p73 tumor suppressor function without altering p73 protein levels. AIP4, an E3 ligase belonging to the HECT domain family, has been reported to be a negative regulatory protein that promotes p73 ub...

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Detalhes bibliográficos
Publicado no:Carcinogenesis
Main Authors: Abou Zeinab, Rami, Wu, H Helena, Abuetabh, Yasser, Leng, Sarah, Sergi, Consolato, Eisenstat, David D, Leng, Roger P
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2021
Assuntos:
Carcinogenesis
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8086772/
https://ncbi.nlm.nih.gov/pubmed/33569599
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/carcin/bgab009
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