Pirh2, an E3 ligase, regulates the AIP4–p73 regulatory pathway by modulating AIP4 expression and ubiquitination

Pirh2 is an E3 ligase belonging to the RING-H2 family and shown to bind, ubiquitinate and downregulate p73 tumor suppressor function without altering p73 protein levels. AIP4, an E3 ligase belonging to the HECT domain family, has been reported to be a negative regulatory protein that promotes p73 ub...

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Detalles Bibliográficos
Publicado en:Carcinogenesis
Autores principales: Abou Zeinab, Rami, Wu, H Helena, Abuetabh, Yasser, Leng, Sarah, Sergi, Consolato, Eisenstat, David D, Leng, Roger P
Formato: Artigo
Lenguaje:Inglês
Publicado: Oxford University Press 2021
Materias:
Carcinogenesis
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC8086772/
https://ncbi.nlm.nih.gov/pubmed/33569599
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/carcin/bgab009
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