Cigarette smoking enhances the metabolic activation of the polycyclic aromatic hydrocarbon phenanthrene in humans

Although it is well established that human cytochrome P450 1 family enzymes are induced by cigarette smoking through activation of the Ah receptor, it is not known whether this leads to increased metabolic activation or detoxification of carcinogenic polycyclic aromatic hydrocarbons (PAH), which are...

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Veröffentlicht in:Carcinogenesis
Hauptverfasser: Luo, Kai, Luo, Xianghua, Cao, Wenhao, Hochalter, J Bradley, Paiano, Viviana, Sipe, Christopher J, Carmella, Steven G, Murphy, Sharon E, Jensen, Joni, Lam, Stephen, Golin, Andrew P, Bergstrom, Lori, Midthun, David, Fujioka, Naomi, Hatsukami, Dorothy, Hecht, Stephen S
Format: Artigo
Sprache:Inglês
Veröffentlicht: Oxford University Press 2020
Schlagworte:
Inflammation, Microenvironment and Prevention
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8086767/
https://ncbi.nlm.nih.gov/pubmed/33319219
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/carcin/bgaa137
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