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Melanoma-specific Expression of the Tumor Suppressor Proteins p16 and PTEN is a Favorable Prognostic Factor in Established Melanoma Brain Metastases

OBJECTIVE: PTEN and p16 frequently undergo (epi)genetic aberrations in melanoma resulting in decreased, or absent, protein levels. We investigated the prognostic significance of these tumor suppressor genes in melanoma brain metastases (MBMs). METHODS: Immunohistochemical analysis was performed on a...

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Detalhes bibliográficos
Publicado no:Melanoma Res
Main Authors: Trembath, Dimitri G., Ivanova, Anastasia, Krauze, Michal T., Kirkwood, John M., Nikolaishvilli-Feinberg, Nana, Moschos, Stergios J.
Formato: Artigo
Idioma:Inglês
Publicado em: 2021
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8086752/
https://ncbi.nlm.nih.gov/pubmed/33871399
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/CMR.0000000000000731
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