A Randomized Phase II Preoperative Study of Autophagy Inhibition With High-Dose Hydroxychloroquine and Gemcitabine/Nab-Paclitaxel in Pancreatic Cancer Patients

PURPOSE: We hypothesized that autophagy inhibition would increase response to chemotherapy in the preoperative setting for patients with pancreatic adenocarcinoma. We performed a randomized controlled trial to assess the autophagy inhibitor hydroxychloroquine in combination with gemcitabine and nab-...

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Detalhes bibliográficos
Publicado no:Clin Cancer Res
Main Authors: Zeh, Herbert, Bahary, Nathan, Boone, Brian A., Singhi, Aatur D., Miller-Ocuin, Jennifer Lee, Normolle, Daniel P., Zureikat, Amer H., Hogg, Melissa E., Bartlett, David L., Lee, Kenneth K., Tsung, Allan, Marsh, J. Wallis, Murthy, Pranav, Tang, Daolin, Seiser, Natalie, Amaravadi, Ravi K., Espina, Virginia, Liotta, Lance, Lotze, Michael T.
Formato: Artigo
Idioma:Inglês
Publicado em: 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8086597/
https://ncbi.nlm.nih.gov/pubmed/32156749
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-19-4042
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