DNA released from neutrophil extracellular traps (NETs) activates pancreatic stellate cells and enhances pancreatic tumor growth

Neutrophil extracellular trap (NET) formation results in the expulsion of granulocyte proteins and DNA into the extracellular space. This process is mediated by the enzyme peptidyl arginine deiminase 4 (PADI4) and translocation of elastase to the nucleus. NET formation, marked by increased levels of...

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Vydáno v:Oncoimmunology
Hlavní autoři: Miller-Ocuin, Jennifer L., Liang, Xiaoyan, Boone, Brian A., Doerfler, W. Reed, Singhi, Aatur D., Tang, Daolin, Kang, Rui, Lotze, Michael T., Zeh, Herbert J.
Médium: Artigo
Jazyk:Inglês
Vydáno: Taylor & Francis 2019
Témata:
Original Research
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6685506/
https://ncbi.nlm.nih.gov/pubmed/31428515
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/2162402X.2019.1605822
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