Safety and Biologic Response of Pre-operative Autophagy Inhibition with Gemcitabine in Patients with Pancreatic Adenocarcinoma

PURPOSE: Autophagy is a cell survival mechanism that plays a critical role in pancreatic carcinogenesis. Murine studies have previously demonstrated that treatment with the late-autophagy inhibitor chloroquine in combination with chemotherapy limited tumor growth. METHODS: In this Phase I/II trial w...

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Dades bibliogràfiques
Publicat a:Ann Surg Oncol
Autors principals: Boone, Brian A., Bahary, Nathan, Zureikat, Amer, Moser, A James, Normolle, Daniel, Wu, Wen-Chi, Singhi, Aatur D., Bao, Phillip, Bartlett, David, Liotta, Lance, Espina, Virginia, Loughran, Patricia, Lotze, Michael T., Zeh, Herbert J.
Format: Artigo
Idioma:Inglês
Publicat: 2015
Matèries:
Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4663459/
https://ncbi.nlm.nih.gov/pubmed/25905586
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1245/s10434-015-4566-4
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