Safety and Biologic Response of Pre-operative Autophagy Inhibition with Gemcitabine in Patients with Pancreatic Adenocarcinoma

PURPOSE: Autophagy is a cell survival mechanism that plays a critical role in pancreatic carcinogenesis. Murine studies have previously demonstrated that treatment with the late-autophagy inhibitor chloroquine in combination with chemotherapy limited tumor growth. METHODS: In this Phase I/II trial w...

Täydet tiedot

Tallennettuna:
Bibliografiset tiedot
Julkaisussa:Ann Surg Oncol
Päätekijät: Boone, Brian A., Bahary, Nathan, Zureikat, Amer, Moser, A James, Normolle, Daniel, Wu, Wen-Chi, Singhi, Aatur D., Bao, Phillip, Bartlett, David, Liotta, Lance, Espina, Virginia, Loughran, Patricia, Lotze, Michael T., Zeh, Herbert J.
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: 2015
Aiheet:
Article
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC4663459/
https://ncbi.nlm.nih.gov/pubmed/25905586
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1245/s10434-015-4566-4
Tagit: Lisää tagi
Ei tageja, Lisää ensimmäinen tagi!

Samankaltaisia teoksia