Clinically relevant enantiomer specific R‐ and S‐praziquantel pharmacokinetic drug‐drug interactions with efavirenz and ritonavir

We conducted a clinical study to determine the effect of efavirenz and ritonavir on the pharmacokinetics of R‐ and S‐PZQ in healthy male participants. This was toward evaluating the risk of drug‐drug interactions, which may occur after PZQ administration to HIV patients on efavirenz or ritonavir con...

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Detalhes bibliográficos
Publicado no:Pharmacol Res Perspect
Main Authors: Mutiti, Chenai Sheilla, Kapungu, Nyasha Nicole, Kanji, Comfort Ropafadzo, Stadler, Nadina, Stingl, Julia, Nhachi, Charles, Hakim, James, Masimirembwa, Collen, Thelingwani, Roslyn Stella
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2021
Assuntos:
Original Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8085964/
https://ncbi.nlm.nih.gov/pubmed/33929078
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/prp2.769
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