Clinically relevant enantiomer specific R‐ and S‐praziquantel pharmacokinetic drug‐drug interactions with efavirenz and ritonavir

We conducted a clinical study to determine the effect of efavirenz and ritonavir on the pharmacokinetics of R‐ and S‐PZQ in healthy male participants. This was toward evaluating the risk of drug‐drug interactions, which may occur after PZQ administration to HIV patients on efavirenz or ritonavir con...

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Publicado en:Pharmacol Res Perspect
Autores principales: Mutiti, Chenai Sheilla, Kapungu, Nyasha Nicole, Kanji, Comfort Ropafadzo, Stadler, Nadina, Stingl, Julia, Nhachi, Charles, Hakim, James, Masimirembwa, Collen, Thelingwani, Roslyn Stella
Formato: Artigo
Lenguaje:Inglês
Publicado: John Wiley and Sons Inc. 2021
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Original Articles
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC8085964/
https://ncbi.nlm.nih.gov/pubmed/33929078
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/prp2.769
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