Computation-guided optimization of split protein systems

Splitting bioactive proteins into conditionally reconstituting fragments is a powerful strategy for building tools to study and control biological systems. However, split proteins often exhibit a high propensity to reconstitute even without the conditional trigger, limiting their utility. Current ap...

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Udgivet i:Nat Chem Biol
Main Authors: Dolberg, Taylor B., Meger, Anthony T., Boucher, Jonathan D., Corcoran, William K., Schauer, Elizabeth E., Prybutok, Alexis N., Raman, Srivatsan, Leonard, Joshua N.
Format: Artigo
Sprog:Inglês
Udgivet: 2021
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8084939/
https://ncbi.nlm.nih.gov/pubmed/33526893
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41589-020-00729-8
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