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Computation-guided optimization of split protein systems
Splitting bioactive proteins into conditionally reconstituting fragments is a powerful strategy for building tools to study and control biological systems. However, split proteins often exhibit a high propensity to reconstitute even without the conditional trigger, limiting their utility. Current ap...
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| I publikationen: | Nat Chem Biol |
|---|---|
| Huvudupphovsmän: | , , , , , , , |
| Materialtyp: | Artigo |
| Språk: | Inglês |
| Publicerad: |
2021
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| Ämnen: | |
| Länkar: | https://ncbi.nlm.nih.gov/pmc/articles/PMC8084939/ https://ncbi.nlm.nih.gov/pubmed/33526893 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41589-020-00729-8 |
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