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Computation-guided optimization of split protein systems
Splitting bioactive proteins into conditionally reconstituting fragments is a powerful strategy for building tools to study and control biological systems. However, split proteins often exhibit a high propensity to reconstitute even without the conditional trigger, limiting their utility. Current ap...
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| Publicado no: | Nat Chem Biol |
|---|---|
| Main Authors: | , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2021
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC8084939/ https://ncbi.nlm.nih.gov/pubmed/33526893 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41589-020-00729-8 |
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