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Functional Elucidation of TfuA in Peptide Backbone Thioamidation

YcaO enzymes catalyze several post-translational modifications on peptide substrates, including thioamidation, which substitutes an amide oxygen with sulfur. The majority of predicted thioamide-forming YcaO enzymes are encoded adjacent to TfuA, which when present, is required for thioamidation. Whil...

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Detalhes bibliográficos
Publicado no:Nat Chem Biol
Main Authors: Liu, Andi, Si, Yuanyuan, Dong, Shi-Hui, Mahanta, Nilkamal, Penkala, Haley N., Nair, Satish K., Mitchell, Douglas A.
Formato: Artigo
Idioma:Inglês
Publicado em: 2021
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8084935/
https://ncbi.nlm.nih.gov/pubmed/33707784
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41589-021-00771-0
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