Safety and target engagement profile of two oxaloacetate doses in Alzheimer’s patients

INTRODUCTION: Brain bioenergetics are defective in Alzheimer’s disease (AD). Preclinical studies find oxaloacetate (OAA) enhances bioenergetics, but human safety and target engagement data are lacking. METHODS: We orally administered 500 or 1000 mg OAA, twice daily for 1 month, to AD participants (n...

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Foilsithe in:Alzheimers Dement
Main Authors: Vidoni, Eric D., Choi, In-Young, Lee, Phil, Reed, Gregory, Zhang, Na, Pleen, Joseph, Mahnken, Jonathan D., Clutton, Jonathan, Becker, Annette, Sherry, Erica, Bothwell, Rebecca, Anderson, Heidi, Harris, Robert A., Brooks, William, Wilkins, Heather M., Mosconi, Lisa, Burns, Jeffrey M., Swerdlow, Russell H.
Formáid: Artigo
Teanga:Inglês
Foilsithe: 2020
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Article
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC8084114/
https://ncbi.nlm.nih.gov/pubmed/32715609
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/alz.12156
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