Pharmacological Targeting of the Mammalian Clock Reveals a Novel Analgesic for Osteoarthritis-Induced Pain

Environmental disruption of the circadian rhythm is linked with increased pain due to osteoarthritis (OA). We aimed to characterize the role of the clock gene in OA-induced pain more systemically using both genetic and pharmacological approaches. Genetically modified mice, (bmal1f/fNav1.8CreERT mice...

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Bibliografski detalji
Izdano u:Gene
Glavni autori: Das, Vaskar, Kc, Ranjan, Li, Xin, Varma, Disha, Qiu, Sujun, Kroin, Jeffrey S., Forsyth, Christopher B., Keshavarzian, Ali, van Wijnen, Andre J., Park, Thomas J., Stein, Gary S., O-Sullivan, Insug, Burris, Thomas P., Im, Hee-Jeong
Format: Artigo
Jezik:Inglês
Izdano: 2018
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Article
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC8082692/
https://ncbi.nlm.nih.gov/pubmed/29474860
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.gene.2018.02.048
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