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3D mesenchymal cell migration is driven by anterior cellular contraction that generates an extracellular matrix prestrain
We describe a cellular contractile mechanism employed by fibroblasts and mesenchymal cancer cells to migrate in 3D collagen gels. During 3D spreading, fibroblasts strongly deform the matrix. They protrude, polarize, and initiate migration in the direction of highest extracellular matrix (ECM) deform...
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| 出版年: | Dev Cell |
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| 主要な著者: | , , , , |
| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
2021
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC8082573/ https://ncbi.nlm.nih.gov/pubmed/33705692 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.devcel.2021.02.017 |
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