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3D mesenchymal cell migration is driven by anterior cellular contraction that generates an extracellular matrix prestrain

We describe a cellular contractile mechanism employed by fibroblasts and mesenchymal cancer cells to migrate in 3D collagen gels. During 3D spreading, fibroblasts strongly deform the matrix. They protrude, polarize, and initiate migration in the direction of highest extracellular matrix (ECM) deform...

Täydet tiedot

Tallennettuna:
Bibliografiset tiedot
Julkaisussa:Dev Cell
Päätekijät: Doyle, Andrew D., Sykora, Daniel J., Pacheco, Gustavo G., Kutys, Matthew L., Yamada, Kenneth M.
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: 2021
Aiheet:
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC8082573/
https://ncbi.nlm.nih.gov/pubmed/33705692
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.devcel.2021.02.017
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