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3D mesenchymal cell migration is driven by anterior cellular contraction that generates an extracellular matrix prestrain

We describe a cellular contractile mechanism employed by fibroblasts and mesenchymal cancer cells to migrate in 3D collagen gels. During 3D spreading, fibroblasts strongly deform the matrix. They protrude, polarize, and initiate migration in the direction of highest extracellular matrix (ECM) deform...

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Detalhes bibliográficos
Publicado no:Dev Cell
Main Authors: Doyle, Andrew D., Sykora, Daniel J., Pacheco, Gustavo G., Kutys, Matthew L., Yamada, Kenneth M.
Formato: Artigo
Idioma:Inglês
Publicado em: 2021
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8082573/
https://ncbi.nlm.nih.gov/pubmed/33705692
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.devcel.2021.02.017
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