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3D mesenchymal cell migration is driven by anterior cellular contraction that generates an extracellular matrix prestrain
We describe a cellular contractile mechanism employed by fibroblasts and mesenchymal cancer cells to migrate in 3D collagen gels. During 3D spreading, fibroblasts strongly deform the matrix. They protrude, polarize, and initiate migration in the direction of highest extracellular matrix (ECM) deform...
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| Publié dans: | Dev Cell |
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| Auteurs principaux: | , , , , |
| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
2021
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC8082573/ https://ncbi.nlm.nih.gov/pubmed/33705692 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.devcel.2021.02.017 |
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