Amyloid-like oligomerization of AIMP2 contributes to α-synuclein interaction and Lewy-like inclusion

Lewy bodies are pathological protein inclusions present in the brain of patients with Parkinson’s disease (PD). These inclusions consist mainly of α-synuclein with associated proteins, such as parkin and its substrate aminoacyl tRNA synthetase complex-interacting multifunctional protein-2 (AIMP2). A...

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Detalhes bibliográficos
Publicado no:Sci Transl Med
Main Authors: Ham, Sangwoo, Yun, Seung Pil, Kim, Hyojung, Kim, Donghoon, Seo, Bo Am, Kim, Heejeong, Shin, Jeong-Yong, Dar, Mohamad Aasif, Lee, Gum Hwa, Lee, Yun Il, Kim, Doyeun, Kim, Sunghoon, Kweon, Hee-Seok, Shin, Joo-Ho, Ko, Han Seok, Lee, Yunjong
Formato: Artigo
Idioma:Inglês
Publicado em: 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8082540/
https://ncbi.nlm.nih.gov/pubmed/33177178
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scitranslmed.aax0091
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