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Amyloid-like oligomerization of AIMP2 contributes to α-synuclein interaction and Lewy-like inclusion
Lewy bodies are pathological protein inclusions present in the brain of patients with Parkinson’s disease (PD). These inclusions consist mainly of α-synuclein with associated proteins, such as parkin and its substrate aminoacyl tRNA synthetase complex-interacting multifunctional protein-2 (AIMP2). A...
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| Udgivet i: | Sci Transl Med |
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| Main Authors: | , , , , , , , , , , , , , , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2020
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC8082540/ https://ncbi.nlm.nih.gov/pubmed/33177178 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scitranslmed.aax0091 |
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