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Aptamer-Driven Toxin Gene Delivery in U87 Model Glioblastoma Cells
A novel suicide gene therapy approach was tested in U87 MG glioblastoma multiforme cells. A 26nt G-rich double-stranded DNA aptamer (AS1411) was integrated into a vector at the 5′ of a mammalian codon-optimized saporin gene, under CMV promoter. With this plasmid termed “APTSAP”, the gene encoding ri...
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| Publicado no: | Front Pharmacol |
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| Main Authors: | , , , , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Frontiers Media S.A.
2021
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC8082512/ https://ncbi.nlm.nih.gov/pubmed/33935695 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphar.2021.588306 |
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