Aptamer-Driven Toxin Gene Delivery in U87 Model Glioblastoma Cells

A novel suicide gene therapy approach was tested in U87 MG glioblastoma multiforme cells. A 26nt G-rich double-stranded DNA aptamer (AS1411) was integrated into a vector at the 5′ of a mammalian codon-optimized saporin gene, under CMV promoter. With this plasmid termed “APTSAP”, the gene encoding ri...

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Veröffentlicht in:Front Pharmacol
Hauptverfasser: di Leandro, Luana, Giansanti, Francesco, Mei, Sabrina, Ponziani, Sara, Colasante, Martina, Ardini, Matteo, Angelucci, Francesco, Pitari, Giuseppina, d’Angelo, Michele, Cimini, Annamaria, Fabbrini, Maria Serena, Ippoliti, Rodolfo
Format: Artigo
Sprache:Inglês
Veröffentlicht: Frontiers Media S.A. 2021
Schlagworte:
Pharmacology
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8082512/
https://ncbi.nlm.nih.gov/pubmed/33935695
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphar.2021.588306
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