Inhibition of Dot1L Alleviates Fulminant Hepatitis Through Myeloid-Derived Suppressor Cells

BACKGROUND & AIMS: Fulminant hepatitis (FH) is a clinical syndrome characterized by sudden and severe liver dysfunction. Dot1L, a histone methyltransferase, is implicated in various physiologic and pathologic processes, including transcription regulation and leukemia. However, the role of Dot1L...

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Gepubliceerd in:Cell Mol Gastroenterol Hepatol
Hoofdauteurs: Yang, Wanlin, Yu, Hongshuang, Huang, Jiefang, Miao, Xiang, Wang, Qiwei, Wang, Yanan, Cheng, Yiji, He, Shan, Zhao, Fang, Meng, Lijun, Wang, Bei, Qian, Fengtao, Ren, Xiaohui, Jin, Min, Gu, Yuting, Zhang, Yanyun, Cai, Wei
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Elsevier 2021
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Original Research
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8081916/
https://ncbi.nlm.nih.gov/pubmed/33497867
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jcmgh.2021.01.013
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