Striatal Dopamine Transporter Function Is Facilitated by Converging Biology of α-Synuclein and Cholesterol

Striatal dopamine transporters (DAT) powerfully regulate dopamine signaling, and can contribute risk to degeneration in Parkinson’s disease (PD). DATs can interact with the neuronal protein α-synuclein, which is associated with the etiology and molecular pathology of idiopathic and familial PD. Here...

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Udgivet i:Front Cell Neurosci
Main Authors: Threlfell, Sarah, Mohammadi, Amir Saeid, Ryan, Brent J., Connor-Robson, Natalie, Platt, Nicola J., Anand, Rishi, Serres, Florence, Sharp, Trevor, Bengoa-Vergniory, Nora, Wade-Martins, Richard, Ewing, Andrew, Cragg, Stephanie J., Brimblecombe, Katherine R.
Format: Artigo
Sprog:Inglês
Udgivet: Frontiers Media S.A. 2021
Fag:
Cellular Neuroscience
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8081845/
https://ncbi.nlm.nih.gov/pubmed/33935654
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fncel.2021.658244
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